2. Signaling Pathways
  3. GPCR/G Protein
  4. Guanylate Cyclase
  5. Guanylate Cyclase Modulator

Guanylate Cyclase Modulator

Guanylate Cyclase Modulators (2):

Cat. No. Product Name Effect Purity
  • HY-159484
    Hsp110/sGC-modulator-1
    		Modulator
    Hsp110/sGC-modulator-1 (compound 17i), an orally active Hsp110/sGC dual-target regulator, exhibits optimal Hsp110 and sGC molecular activities as well as remarkable cell malignant phenotypes inhibitory and vasodilatory effects. Hsp110/sGC-modulator-1 (compound 17i) attenuates pulmonary vascular remodeling and right ventricular hypertrophy via Hsp110 suppression.
  • HY-149453
    MCUF-651
    		Modulator 99.85%
    MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy.